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Oct 5, 2019
Category: General
Posted by: admin

The Teachers day was celebrated in Department on 05-Sep-2019 and Microbiology day on 26-Sep-2019. The details of celebrations and pictures are here and here.

Sep 14, 2019
Category: General
Posted by: admin

The puzzle for Sep 2019 was created by Babbal and Shilpa Mohanty (both PhD Students). The competition was held on 13-Sep-2019 and the winners are- First: Aparajita, and Second: Nupur and Tanu. More details here.

Aug 31, 2019
Category: General
Posted by: admin

The admission process is now over for M.Sc. Microbiology program, for academic year 2019-20.

CMS - 2.2.7 - Skookumchuck
 

Dr. Rajeev Kaul

Dr.Rajeev Kaul

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Email: rkaul@south.du.ac.inRajeevPic
Phone: 011-24157328

Area of research: Virus pathogenesis, Tumor Virology

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Research description:

Our lab is presently working to study biology of cancers mediated by viruses, and molecular basis of virus mediated host immuno-suppression. Tumor viruses have provided relatively simple genetic systems, which can be manipulated for understanding the molecular mechanisms of the cellular transformation process. A growing body of information in the tumor virology field provides several prospects for rationally targeted therapies. However, further research is needed to better understand the multiple mechanisms utilized by these viruses in cancer progression in order to develop therapeutic strategies. The major focus of our lab is to investigate virus host interactions using various tools including cell culture system and mice models. Primarily, we study three human tumor associated viruses, Epstein Barr Virus (EBV), Kaposi sarcoma associated herepesvirus (KSHV), and Hepatitis C Virus (HCV). In particular, we are using genetic, genomic, proteomic and biochemical approaches to identify viral pathways involved in these cellular events to develop mechanistic models for transformation by viruses. Tumor associated viruses provide a unique opportunity to understand the role played by viral proteins in transformation and to identify pathways critical for tumorigenesis and metastasis. A clear understanding of the pathways most critically involved in tumor formation and progression and the consequences of altered cell behavior in the tissue micro-environments will provide nuggets of information which will help us in formulating better therapeutic approaches. It is likely that a combination of therapeutic agents targeting multiple signal transduction pathways will be needed for maximum therapeutic benefits.

In addition, we have recently initiated work on understanding the molecular basis of peste-des-petits ruminants virus (PPRV) mediated host immune modulation for the development of next generation vaccine. Immuno-suppression and innate immunity control by morbilliviruses such as PPRV in small ruminants and measles in human remains a leading cause of death among infected host because it suppresses immune function, facilitating secondary infections. The basic mechanisms underlying PPRV-induced immunosuppression are poorly understood. The extent of viral replication documented in immune cells implies that it can directly cause immunosuppression. Our central hypothesis is that these viruses have evolved a multi-pronged host cell control strategy that allow them to replicate to high levels in host cells and induce generalized immunosuppression by interfering in cellular immune signaling pathways. The work will be important for more comprehensive understanding of basic cellular processes, in addition to providing us with targets to focus for development of anti-viral therapeutics and better safer non-immunosuppressive vaccines. The implications of the generated knowledge will extend beyond the morbillivirus field to include immunology, and cell biology. Small genome, simple organization and life cycle of morbilliviruses permits their use as a tool to dissect complex cellular pathways and to determine basic aspects of immune response induction. The research will lead to generation of information which can be used for development of approaches resulting in improvement of animal health and herd immunity.

 

Select Publications:

Rajeev Kaul, Pravinkumar Purushothaman, Timsy Uppal and Subhash C. Verma (2019). KSHV lytic proteins K-RTA and K8 bind to cellular and viral chromatin to modulate gene expression. PLOS One, Apr 18;14(4):e0215394. doi: 10.1371/journal.pone.0215394

Catrherine Paul, Lohit Khera, Rajeev Kaul (2019). Hepatitis C virus core protein interacts with cellular metastasis suppressor Nm23-H1 and promotes cell migration and invasion. Arch Virol. 2019 Mar 11. doi: 10.1007/s00705-019-04151-x.

Nivedita Gaur, Tanvi Tikla, Rajeev Kaul (2018). Kaposi sarcoma‑associated herpes virus (KSHV) latent protein LANA modulates cellular genes associated with epithelial‑to‑mesenchymal transition. Arch Virol. https://doi.org/10.1007/s00705-018-4060-y.

Sharvan Sehrawat and Rajeev Kaul (2018). Veterinarians as scientific contributors in mainstream biomedical research. Current Science, Vol 115 (4), 2018, 616-617.

Lohit Khera, Catherine Paul, Rajeev Kaul (2018). Hepatitis C Virus mediated metastasis in hepatocellular carcinoma as a therapeutic target for cancer management. Current Drug Metabolism. 19: (DOI: 10.2174/1389200219666180129110942).

Lohit Khera, Catherine Paul, Rajeev Kaul (2017). Hepatitis C Virus E1 protein promotes cell migration and invasion by modulating cellular metastasis suppressor Nm23-H1. Virology. 506:110-120 

Jaya Gandhi, Lohit Khera, Nivedita Gaur, Catherine Paul, Rajeev Kaul (2017). Role of Modulator of Inflammation Cyclooxygenase-2 in Gammaherpesvirus Mediated Tumorigenesis. Front. Microbiol. | doi: 10.3389/fmicb. 00538

Jaya Gandhi, Nivedita Gaur, Lohit Khera, Rajeev Kaul*, Erle Robertson* (*Co-corresponding authors). (2015). COX-2 induces lytic reactivation of Epstein Barr Virus through Prostaglandin E2 by modulating the EP receptor signalling Pathway. Virology. 484: 1-14

Nivedita Gaur, Jaya Gandhi, Erle S Robertson, Subhash C Verma, Rajeev Kaul (2014). Epstein Barr Virus latent antigens EBNA3C and EBNA1 modulate epithelial to mesenchymal transition of cancer cells associated with tumour metastasis. Tumor Biology. 36(4):3051-60. 

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